Pharmacotherapy Treatment Of Alzheimer s - 1541 Words

604301973 Pharmacotherapy Treatment of Alzheimer’s: Donepezil A disease that sweeps across the nation and affects nearly 80% of the population ages 60 and up is known as Alzheimer’s. A misconception that many people believe about Alzheimer’s is that it is a part of getting older. It is not true. Alzheimer’s is an intricate neurodegenerative disorder associated with â€Å"protein misfolding and aggregation, oxidative stress, mitochondrial abnormalities and neuroinflammatory process at a molecular level† and â€Å"synaptic loss, cholinergic dysfunction, and abnormal protein depositions in the brain†. Some symptoms associated with this disease are delusion, inability to recall or retain information, mental decline, aggression, personality changes, mood swings, and etc. Though there are currently no cures for Alzheimer’s, cholinesterase inhibitors such as donepezil, galantamine, rivastigmine and NMDA receptor antagonist memantine are used as pharmac otherapy treatment to slow down the progression and temporarily alleviate symptoms. This essay is primarily focused on Donepezil and the cognitive alleviation it results in for patients with Alzheimer’s. The first part of the paper will summarize two preclinical and two clinical trials done on Donepezil to subjects with Alzheimer’s or Alzheimers like symptoms. The second part will describe the implications and future directions from all the results obtained. The first article summarized is â€Å"Donepezil-induced improvement in delayed matchingShow MoreRelatedSymptoms And Progression Of Alzheimer s Disease Essay2254 Words   |  10 Pageswill triple by 2050. Alzheimer s is the most common form of dementia, a general term for memory loss and other intellectual abilities serious enough to interfere with daily life. Alzheimer s disease accounts for 60 to 80 percent of dementia cases. The number of Americans living with Alzheimer s disease is growing and growing fast. An estimated 5.4 million Americans of all ages have Alzheimer s disease in 2016. Of the 5.4 million Americans with Alzheimer s, an estimated 5.2 million peopleRead MoreThe Effects Of Resveratrol And Its Effect On The Risk Of Neurodegeneration, And Alzheimer s Disease1138 Words   |  5 Pagesanti-inflammatory, anti-viral, and anti-cancer properties. Although resveratrol was first isolated in 1940, it was not until the last decade that it was recognised for its potential therapeutic role in reducing the risk of neurodegeneration, and Alzheimer s disease (AD) in particular. AD is the primary cause of progressive dementia. Resveratrol has demonstrated neuroprotective effects in s everal in vitro and in vivo models of AD. Apart from its potent antioxidant and anti-inflammatory roles, evidenceRead MoreMajor Depressive Disorder ( Mdd )2192 Words   |  9 Pagesphysical and mental health problems, such as substance abuse, suicidal ideations and catatonic behaviours. A patient with major depression can be treated using different treatment methods, such as pharmacological, cognitive-behavioral therapy (CBT), group therapy, interpersonal therapy and Electroconvulsive therapy. Each treatment benefits a patient struggling with depression in a different way depending on a patient’s compliance and social support. In this paper, I am going to present ECT as anRead MoreAlzheimers Disease Essay2087 Words   |  9 Pagesfatal dementia, is characterized by progressive cognitive decline. While AD is the most common form of dementia, its prevalence has only recently been recognized. When Alois Alzheimer first described the sequence of changes in 1907, physicians be lieved the disease to be an extremely rare, mid-life condition. It wasn’t until the 1970’s that the same types of changes were shown to occur in both late- and early-onset forms (Cavanaugh et.al. 2008). As such, almost all knowledge of AD has been learned withinRead MoreMicroglial and Neurological Disorder2037 Words   |  9 Pagestransplantation in the treatment of neurodegerative diseases. (ref) Transplanted cell does not act directly through replenishment of loss neuron but via restoration of microglial homeostasis and induced secretion of neurotrophic factors and pro- survival cytokines. (ref) Also, the transplanted cell could be further exploited as vehicle to deliver therapeutics genes to the CNS milieu thus enhanced the treatment outcome and to prevent the progressive of the disease. Apart from management and treatment of neurodegenerative